Best 5-MTHF Vitamin B9 Supplements of 2026

Phoebe Cooper Avatar
Phoebe Cooper
Last Updated: 6 Feb 2026

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5-MTHF Vitamin B9 Supplements are a type of dietary supplement that provides an active form of folate, a B-vitamin that plays a crucial role in many bodily processes. Unlike other types of folate supplements, which need to be converted into the active form by the body, 5-MTHF is already in the active form and can be readily used by the body. These supplements are often recommended for individuals who may have difficulty converting regular folate into the active form due to genetic variations or other factors. They are available in various strengths and formulations, and can be found in both tablet and capsule form.

At a Glance: Our Top Picks

Igennus Pure Methyl Folate 400 mcg Tablets Cover #TOP 1
Igennus Pure Methyl Folate 400 mcg Tablets
ftb score rating icon 9.9
Folate 400μg Capsules for Pregnancy Cover #TOP 2
Folate 400μg Capsules for Pregnancy
ftb score rating icon 9.8
Folate (L-Methylfolate) 1000μg Capsules by Health Leads Cover #TOP 3
Folate (L-Methylfolate) 1000μg Capsules by Health Leads
ftb score rating icon 9.6

Top 10 5-MTHF Vitamin B9 Supplements

Igennus Pure Methyl Folate 400 mcg Tablets

IGN270
Cream Beige
Igennus Pure Methyl Folate 400 mcg Tablets Cover
Igennus Clean Methyl Folate 400 mcg, 180 Tablets, Methylated Form of Folic Acid 5-MTHF (Vitamin B9), Vegan, Suitable for Pregnancy, Pure Formula, One-a-Day, 6 Month Supply

Igennus Methyl Folate Tablets provide a bioavailable form of L-Methylfolate, which is highly absorbable, ensuring you achieve 1.8 times higher blood levels compared to standard folic acid. With a clean formula, these tablets contain only hypoallergenic ingredients, making them vegan and free from unnecessary additives. The ideal dose of 400 mcg taken once a day supports long-term use and meets 200% of the Nutrient Reference Value. This supplement is particularly beneficial during pregnancy, as folate plays a crucial role in normal tissue growth and helps reduce fatigue.

What We Like
Highly absorbable folate form
Vegan and non-GMO ingredients
Convenient one-a-day dosage
Supports pregnancy health
Expertly formulated for quality

Folate 400μg Capsules for Pregnancy

Health Leads ...Working With Nature
Folate 400μg Capsules for Pregnancy Cover
Folate (L-Methylfolate) 400μg x 90 Capsules - 5-MTHF Active Form of Folic Acid/Vitamin B9 - Supports Normal Maternal Tissue Growth During Pregnancy - PRENATAL- Magnesium Stearate Free - Made in Wales

Health Leads Folate Capsules provide a pioneering additive-free supplement, manufactured in Wales to ensure quality and purity. These capsules are essential for women trying to conceive or during early pregnancy, as the World Health Organisation recommends a daily intake of 400μg of folic acid to support maternal tissue growth. The active form of folic acid, 5-MTHF, is more effectively absorbed by your body. With a commitment to high standards, you can trust these supplements for your health and wellbeing.

What We Like
Additive-free formulation
Made in Wales
Active 5-MTHF form
Supports pregnancy health
Quality-controlled manufacturing

Folate (L-Methylfolate) 1000μg Capsules by Health Leads

Health Leads ...Working With Nature
0520
Folate (L-Methylfolate) 1000μg Capsules by Health Leads Cover
Folate (L-Methylfolate) 1000μg x 90 Capsules, 5-MTHF Active Form of Folic Acid/Vitamin B9, Please See Our 400mcg Version for Pregnancy, Magnesium Stearate Free, Made in Wales

The Health Leads Folate Capsules provide a pioneering additive-free supplement option, made in Wales with a focus on quality and purity. Featuring 5-MTHF, the active form of folic acid, these capsules ensure better absorption, which is beneficial for your overall health. This product is particularly useful for women trying to conceive, as folic acid is crucial during pregnancy. With a commitment to high standards, you can trust that you are choosing a reliable supplement to support your nutritional needs.

What We Like
Additive-free formula
Better absorption of folate
Supports pregnancy health
Manufactured in Wales
#TOP 4

Carlyle L Methylfolate 1000ug Vegan Tablets

CU81271
Carlyle L Methylfolate 1000ug Vegan Tablets Cover
Methyl Folate 1000ug | 120 Vegan Tablets (4 Months Supply) | L-Methylfolate as a Active Form of Folic Acid 5-MTHF (Vitamin B9) | No Artificial Preservatives | by Carlyle

Carlyle Methylfolate Tablets offer a potent 1000mcg of Folic Acid in each tablet, ensuring you receive a high-strength dose. The active form, known as 5-MTHF, is more effectively absorbed by your body, making it beneficial for your overall health. Expertly crafted, this product is designed with purity and potency in mind, providing you with confidence in its quality. Furthermore, the tablets are free from artificial colours, flavours, or preservatives, making them an excellent choice for adults seeking a natural supplement.

What We Like
High strength dosage
Better absorption
Pure and natural ingredients
Vegan-friendly
#TOP 5

Epigenetics 5-MTHF High Strength Vitamin B9 Drops 1000mcg

Epigenetics 5-MTHF High Strength Vitamin B9 Drops 1000mcg Cover
5-MTHF 100ml | High Strength Folic Acid as 5-Methyltetrahydrofolate Vitamin B9 Liquid Drops 1000mcg | Methylfolate Made in UK & Vegan Friendly | Over 4 Months Supply.

Epigenetics 5-MTHF Drops offer a bioactive form of folic acid, which means the vitamin B9 is already in its active, methylated form for your body to use immediately. This is especially helpful if you have difficulty converting standard folic acid. The drops are essential for maternal health, supporting healthy fetal development by boosting folate levels, which reduces the risk of neural tube defects during pregnancy. Thanks to its liquid formula, you can enjoy effortless absorption and easy, precise dosing with the included glass pipette, making it a convenient alternative to tablets or capsules.

What We Like
Active methylated folate form
Supports healthy pregnancy
Easy liquid absorption
Precise dosing pipette
Long-lasting supply
#TOP 6

Methyl Folate 600µg Quatrefolic Supplement

SB-465-MethyFol
Methyl Folate 600µg Quatrefolic Supplement Cover
Methyl Folate 600µg - 90 Capsules as Quatrefolic 5-MTHF Supplement 6S-5-methyltetrahydrofolate – The 4th Generation of Folate a Highly biologically Active Form of Folic Acid/Vitamin B9 - UK Made

Quatrefolic Methyl Folate is a highly effective vitamin B9 supplement that offers a potent daily dose of 600µg. Its superior water solubility ensures better absorption into your bloodstream, making it readily available for your body’s use. Unlike standard folic acid, it doesn't require conversion, providing immediate benefits. The capsules are made from high-quality ingredients, free from gluten, yeast, and lactose, making them suitable for both vegetarians and vegans. This ensures you receive a pure and premium product for your health.

What We Like
High water solubility
Immediate availability in the body
Pure, high-quality ingredients
Suitable for vegetarians and vegans
#TOP 7

Freak Athletics Folate 1000mcg Capsules

Freak Athletics Folate 1000mcg Capsules Cover
Folate 1000mcg (L-Methylfolate) 120 Capsules, 5-MTHF Active Form of Folic Acid/Vitamin B9

The Freak Athletics Folate is a high-quality supplement providing 1000mcg of the active form of folic acid, 5-MTHF. This form is better absorbed by your body, ensuring you receive the benefits of Vitamin B9 effectively. The easy-to-swallow capsules make it convenient for daily use, so you can easily incorporate it into your routine. Manufactured in the UK with premium quality ingredients, you can trust that you are consuming a safe and reliable product that supports your health goals.

What We Like
Active 5-MTHF form
Easy-to-swallow capsules
High-quality ingredients
Manufactured in the UK
Supports health goals
#TOP 8

5MG L-5 MTHF Activated Folic Acid Supplement

0647297429925
White
5MG L-5 MTHF Activated Folic Acid Supplement Cover
5MG L-5 MTHF by Intelligent Labs, L-5 Methylfolate Activated Folic Acid Supplement as Quatrefolic Acid, Activated Folate

The 5MG L-5 MTHF Supplement by Intelligent Labs offers a scientifically advanced solution for those with MTHFR issues. It features Quatrefolic Acid, which is better absorbed than traditional forms, providing you with the essential nutrients your body needs. Each vegetarian capsule contains a high strength of 5mg of activated folic acid, supporting your energy levels and maintaining a healthy immune system. With independent testing confirming its purity, you can trust this product to help enhance your overall well-being.

What We Like
Highly absorbable formula
Supports energy and immune function
Contains 5mg of activated folate
Third-party tested for safety
#TOP 9

Epigenetics 5-MTHF Delayed Release 1000mcg Capsules

Epigenetics 5-MTHF Delayed Release 1000mcg Capsules Cover
5-MTHF Delayed Release Capsules | 1000mcg High Strength Folic Acid as 5-Methyltetrahydrofolate Vitamin B9 | Methylfolate Made in UK & Vegan Friendly | 2 Months Supply | 60 Capsules

Epigenetics 5-MTHF Capsules provide a bioactive form of folic acid, known as 5-MTHF, which your body can use immediately. This is especially helpful if you have difficulty converting regular folic acid due to genetic factors. The capsules support maternal health by boosting folate levels, important for healthy fetal development and reducing risks during pregnancy. With convenient delayed release capsules, you get smooth and accurate dosing. Plus, each pot offers a generous two-month supply, making it easy to maintain your daily intake without fuss.

What We Like
Bioactive folic acid form
Supports maternal health
Convenient delayed release
Two-month supply
Made in UK, vegan-friendly

Jarrow Formulas Methyl Folate Vegan Capsules

JFO-0280
50 g (Pack of 1)
Jarrow Formulas Methyl Folate Vegan Capsules Cover
Jarrow Formulas Methyl Folate (5-MTHF), 400mcg, Minerals Supplement, 60 Vegan Capsules, Gluten Free, Vegetarian, Soy Free, Non-GMO, Vitamin B9, Folic Acid

Jarrow Formulas Methyl Folate offers a high dosage of 680mcg of folate DFE in just one vegan capsule, providing a convenient daily supplement. This product boasts excellent bioavailability, ensuring that your body can effectively absorb the nutrients. Each capsule is rigorously tested in independent laboratories, guaranteeing quality and purity for peace of mind. Furthermore, it is gluten-free and free from genetic engineering, making it a suitable choice for those with dietary restrictions.

What We Like
High dosage in one capsule
Good bioavailability
Independently lab tested
Gluten-free and non-GMO
Buying Guide Image
Editor's Notes

During our 5-mthf vitamin b9 supplement research, we found 65 5-mthf vitamin b9 supplement products and shortlisted 10 quality products. We collected and analyzed 9,117 customer reviews through our big data system to write the 5-mthf vitamin b9 supplements list. We found that most customers choose 5-mthf vitamin b9 supplements with an average price of £15.05.

The 5-mthf vitamin b9 supplements are available for purchase. We have researched hundreds of brands and picked the top brands of 5-mthf vitamin b9 supplements, including Igennus Healthcare Nutrition, Health Leads ...Working With Nature, Carlyle, Epigenetics, swiss bioenergetics.

Written by
Phoebe Cooper Avatar

In 2000, Phoebe Cooper graduated from the University of London as a Pharmacist. She practiced as a Pharmacist for the better part of 2 decades. Phoebe says she has worked in the majority of health sectors and has sufficient accumulated knowledge and experience. In her practice, Phoebe published a series of eBooks, one of which is titled "Good Health Good Living."