Best Glycolic Acid Night Creams of 2025

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Glycolic acid night creams are a type of skincare product that contains glycolic acid, an alpha-hydroxy acid that is derived from sugar cane. These creams are designed to be used at night, when the skin is most receptive to active ingredients, to help exfoliate and rejuvenate the skin. Glycolic acid is known for its ability to penetrate deeply into the skin, helping to unclog pores, smooth fine lines and wrinkles, and even out skin tone. While these creams can be beneficial for most skin types, those with sensitive skin may want to exercise caution, as glycolic acid can be irritating.
At a Glance: Our Top Picks
Top 8 Glycolic Acid Night Creams
ISISPHARMA GLYCO-A Intense Peeling Night Cream
GLYCO-A Intense Peeling is a powerful night cream designed for mature skin. With a high concentration of 25% glycolic acid, it effectively fades wrinkles and pigmentation spots, helping you achieve a smoother complexion. Using this cream 2 to 3 times a week can significantly reduce sagging skin. The glycolic acid also promotes cell renewal and stimulates collagen production, which is essential for maintaining youthful skin. Dermatologically tested and suitable for sensitive skin, this cream provides a safe and effective way to rejuvenate your appearance.
Revolution Beauty Glycolic Acid Overnight Cream
The Revolution Skincare Overnight Cream is your ideal companion for achieving smooth and radiant skin. Formulated with 7% Glycolic acid, it helps to enhance your skin's texture, giving you a more polished look by morning. Squalane is included to ensure your skin feels soft and supple without any greasy residue. Additionally, allantois works to comfort and soothe dry or irritated skin, making this cream perfect for night-time use. Over time, you may notice a more even skin tone, which adds to the overall effectiveness of this luxurious treatment.
ISISPHARMA GLYCO-A Night Cream for Blemish-Prone Skin
The ISISPHARMA GLYCO-A Night Cream is a powerful skincare solution designed for combination, oily, and blemish-prone skin. With a 12% glycolic acid concentration, this night cream effectively reduces sebum levels and matifies your skin, helping to diminish post-acne marks. Its glycolic acid works as a potent exfoliant, smoothing your skin's surface and promoting cell renewal, leaving your complexion looking radiant. Additionally, this treatment is simple to use; just apply a thin layer in the evening after cleansing, and enjoy the benefits overnight without the need to rinse.
RoC Retinol Correxion Night Cream for Radiant Skin
The RoC Night Cream is your nightly ally for achieving smoother, more radiant skin. It works while you sleep, optimising the skin's natural repair process. Clinically proven, this cream visibly reduces fine lines and wrinkles over time, ensuring you see noticeable improvements within just four weeks. With its unique formula containing pure RoC Retinol, this cream enhances skin renewal, helping you wake up to a revitalised complexion every morning.
Hyaluron Face Lift Night Cream with Peptides
The bioniva Night Cream is a high-quality anti-ageing solution crafted with vegan and natural ingredients. It features peptides and botanical hyaluronic acid that work to restore firmness and elasticity to your skin, helping to reduce the appearance of wrinkles. This cream is suitable for all skin types, including sensitive skin, as it absorbs quickly and provides intense nourishment without clogging pores. Plus, it is free from synthetic fragrances, making it gentle on your skin while still delivering effective results.
ISISPHARMA GLYCO-A Soft Peeling Night Cream
ISISPHARMA's GLYCO-A Soft Peeling night cream offers a gentle at-home peel with a 5.5% concentration of glycolic acid. This cream is perfect for those new to peels and helps to brighten the skin while purifying it. By applying a thin layer in the evening, you can enjoy smoother skin texture and clearer pores without the need to rinse. Its powerful glycolic acid works to exfoliate, removing dead skin cells and promoting cell renewal, giving your skin a youthful glow.
Dr Irena Eris Lumissima Night Cream for Mature Skin
The Dr Irena Eris Night Cream is designed to hydrate and nourish your skin while you sleep. It works effectively to reduce the appearance of wrinkles, helping you achieve a smoother complexion. Additionally, this cream targets hyperpigmentation, making it an excellent choice for those looking to even out their skin tone. With its blend of beneficial ingredients, you can wake up to a revitalised, youthful glow every morning.
Yon-Ka Glyconight Night Mask Peel 10%
The Yon-Ka Glyconight Mask is a powerful overnight peel that effectively reduces signs of ageing, helping you achieve a plump and glowing complexion. With its 10% pure glycolic acid, it works to eliminate dead skin cells and refine your skin’s texture, making it an excellent choice for smoothing out wrinkles. Dermatologically proven results show a significant reduction in wrinkle depth and pore size after just one month of use. This clean, vegan formula ensures you can enjoy professional skincare from the comfort of your home.
Frequently Asked Questions (FAQs)
1. Can I use glycolic acid cream every night?
Face wash with glycolic acid has a low concentration of acid (usually 8–10% or less) so it's safe to use nightly.
2. Should glycolic acid be used at night?
As for whether you should apply glycolic acid morning or night, we recommend applying it as part of your evening skincare routine. Glycolic acid can cause “photosensitivity,” which means it makes your skin more sensitive to the sun's UV rays, upping your chances of a sunburn or skin damage.
3. Which is the best glycolic acid cream?
Best Glycolic Acid Products. Best Drugstore: L'Oréal Paris Revitalift Derm Intensives 10% Pure Glycolic Acid Serum.Best Derm-Approved: SkinCeuticals Retexturing Activator Replenishing Serum.Best Budget: The INKEY List Glycolic Acid Exfoliating Toner.
4. What does glycolic night serum do?
Framboos Glycolic Night Serum is a high-tech 10% AHA/1% BHA gel that resurfaces dull, congested skin by gently lifting away dead skin cells, dramatically improving the appearance of skin's tone and texture, fine lines, wrinkles, and pores.
During our glycolic acid night cream research, we found 24 glycolic acid night cream products and shortlisted 8 quality products. We collected and analyzed 11,814 customer reviews through our big data system to write the glycolic acid night creams list. We found that most customers choose glycolic acid night creams with an average price of £13.35.
The glycolic acid night creams are available for purchase. We have researched hundreds of brands and picked the top brands of glycolic acid night creams, including IsisPharma, Revolution Skincare London, RoC, bioniva, Dr. Irena Eris. The seller of top 1 product has received honest feedback from 231 consumers with an average rating of 4.9.

Charlotte Powell is a dermatologist and a licensed cosmetologist from Westminster, London. However, she was first a cosmetologist from London Beauty Training School. According to Charlotte, she needed better insight into the human skin, hence the dermatology degree. Long before she acquired her degree, she wrote and edited articles, eBooks, and editorials for companies and websites. Charlotte combines her skill and knowledge in providing DIY Beauty tips amongst other fashion related topics.