Best St. John's Wort Supplements of 2025

Phoebe Cooper Avatar
Phoebe Cooper
Last Updated: 11 Feb 2025

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St. John's Wort supplements are a type of herbal supplement that are derived from the flowering plant Hypericum perforatum. These supplements are commonly used to help alleviate symptoms of depression, anxiety, and sleep disorders. St. John's Wort supplements are available in various forms, including capsules, tablets, and teas. While these supplements are generally considered safe for most people, it is important to speak with a healthcare professional before taking them, especially if you are currently taking any prescription medications.

At a Glance: Our Top Picks

Natures Aid Ucalm St John's Wort Tablets for Mood Relief Cover #TOP 1
Natures Aid Ucalm St John's Wort Tablets for Mood Relief
ftb score rating icon 9.9
HRI Good Mood Tablets for Low Mood Relief Cover #TOP 2
HRI Good Mood Tablets for Low Mood Relief
ftb score rating icon 9.8
Schwabe KarmaMood Maximum Strength St John's Wort Cover #TOP 3
Schwabe KarmaMood Maximum Strength St John's Wort
ftb score rating icon 9.6

Top 10 St. John's Wort Supplements

#TOP 1

Natures Aid Ucalm St John's Wort Tablets for Mood Relief

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Natures Aid Ucalm St John's Wort Tablets for Mood Relief Cover
Natures Aid Ucalm St John's Wort, Relief of Symptoms of Slightly Low Mood and Mild Anxiety, Vegan, 120 Tablets

Natures Aid Ucalm Tablets are designed to help relieve symptoms of slightly low mood and mild anxiety. Each tablet contains 300 mg of extract from St John's Wort, providing a natural option for those seeking emotional balance. You will find it convenient to take just two tablets once a day, making it easy to incorporate into your routine. Made in the UK to high pharmaceutical standards, these tablets are suitable for both vegetarians and vegans, offering a health-conscious choice.

What We Like
Supports low mood relief
Helps with mild anxiety
Convenient daily dosage
Vegan and vegetarian friendly
#TOP 2

HRI Good Mood Tablets for Low Mood Relief

HRI
unifun
HRI Good Mood Tablets for Low Mood Relief Cover
HRI Good Mood 60 Tablets - to Relieve The Symptoms of Slightly Low Mood and Mild Anxiety - 334 mg of St John's Wort Extract, Equivalent to 1670mg – 2338mg of St John’s Wort. 1 Pack

HRI Good Mood offers a traditional herbal remedy to help relieve slightly low mood and mild anxiety. With the strongest daily dose available on the UK market, you can take one or two tablets a day, depending on your needs. The easy-to-swallow tablets are suitable for both vegetarians and vegans, making them accessible for a wide range of users. Furthermore, these tablets are backed by the THR logo, ensuring quality and safety through rigorous testing.

What We Like
Effective for low mood relief
Highest dose of St John's Wort
Easy to swallow
Suitable for vegetarians and vegans
Registered for quality and safety
#TOP 3

Schwabe KarmaMood Maximum Strength St John's Wort

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1 count (Pack of 1)
Schwabe KarmaMood Maximum Strength St John's Wort Cover
Schwabe KarmaMood Maximum Strength - St John's Wort Extract 425mg - Traditional Herbal Medicinal Product - 60 Tablets

Schwabe KarmaMood is a high-strength St John's Wort supplement, offering 425mg of extract per tablet. This traditional herbal medicinal product is commonly used to help alleviate low mood and mild anxiety, providing you with a natural option for emotional support. Each tablet is foil blister packed, ensuring that it retains its freshness and potency, so you can feel confident in its effectiveness. Formulated by expert pharmacists at Schwabe Pharma, this product prioritises quality and reliability for your wellbeing.

What We Like
High strength formulation
Helps with low mood
Alleviates mild anxiety
Foil packed for freshness
Pharmacist formulated
#TOP 4

Fitness Health St John's Wort Tablets for Mood Relief

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Fitness Health St John's Wort Tablets for Mood Relief Cover
Fitness Health ST Johns Wort Tablets | Relief of Slightly Low Mood & Mild Anxiety | High Strength Supplement | Vegan Tablets & UK Made | High Strength St. John's Wort Supplement | 1000MG (90 Tablets)

Fitness Health St John's Wort is a high-strength supplement designed to aid slightly low mood and mild anxiety. Made from the flowering herb known as ‘the amber healer’, these tablets contain beneficial substances like hypericin and hyperforin. You can take two tablets for maximum strength or one for a gentler dose, providing you with flexibility. The formulation has been improved for faster absorption, ensuring you can feel like yourself again throughout the day.

What We Like
High-strength herbal formulation
Vegan and UK-made
Quick-acting and absorbable
Convenient recyclable packaging
#TOP 5

Schwabe KarmaMood Maximum Strength St John's Wort

SCHKARQ44
1 count (Pack of 1)
Schwabe KarmaMood Maximum Strength St John's Wort Cover
Schwabe KarmaMood Maximum Strength - St John's Wort Extract 425mg - Traditionally Used for Low Mood and Mild Anxiety - Traditional Herbal Medicinal Product - 30 Tablets

Schwabe KarmaMood is a herbal medicinal product designed to help relieve slightly low mood and mild anxiety. It features St John's Wort, a well-known herb that contains beneficial compounds like hypericin and hyperforin. This product is registered under the Traditional Herbal Registration Scheme, ensuring you receive a trusted remedy. You can rely on its high-quality, plant-based ingredients, as it is vegan-friendly and free from common allergens, providing peace of mind while addressing your mood and anxiety concerns.

What We Like
Traditionally used for mood support
High-quality, plant-based ingredients
Registered herbal medicine
Vegan and allergen-free
#TOP 6

Hepatica St John's Wort 5,000mg Capsules

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Hepatica St John's Wort 5,000mg Capsules Cover
St Johns Wort 5,000mg Equivalent (500mg of 10:1 Extract) 180 Vegan Capsules, 3rd Party Lab Tested, Maximum Strength Supplement

Hepatica St John's Wort is a high-quality supplement designed to support your well-being. It is independently laboratory tested to ensure it is free from harmful contaminants, providing peace of mind. The capsules, unlike tablets, do not have an unpleasant taste and offer maximum protection for sensitive ingredients. Each container contains 180 vegan capsules, giving you a generous six-month supply, making it a great value compared to competitors.

What We Like
Lab tested for safety
Vegan-friendly capsules
180 capsules per container
No unpleasant taste
Great value for money
#TOP 7

St John's Wort 1000mg Supplement Tablets

St John's Wort 1000mg Supplement Tablets Cover
St John`s Wort 1000mg (60 Tablets) - St. Johns Wort Supplement - Flat Pack, Letterbox Friendly - Suitable for Vegans and Vegetarians

The St John's Wort Tablets are designed to support your emotional well-being with a standardized extract containing 0.3% hypericin. These easy-to-swallow tablets are ideal for those seeking a convenient supplement. Being non-GMO and gluten-free, you can feel confident in their quality and suitability for your dietary needs. Plus, they are made in a GMP certified facility, ensuring that you receive a reliable product every time.

What We Like
Supports emotional well-being
Easy to swallow
Non-GMO and gluten-free
Vegan and vegetarian friendly
Letterbox friendly delivery
#TOP 8

Vegavero L-Tyrosine with B Vitamins

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Vegavero L-Tyrosine with B Vitamins Cover
Vegavero L-Tyrosine 1200 mg | with Iodine, Selenium & B Vitamins | Brain & Focus Supplement | 180 Capsules | Vegan

Vegavero L-Tyrosine is a potent brain and focus supplement that delivers 1200 mg of L-Tyrosine along with five essential B vitamins. This strong combination helps reduce fatigue and supports your energy metabolism, making it easier for you to stay motivated. The inclusion of iodine and selenium further enhances cognitive function, allowing for improved mental performance. With laboratory-tested, vegan capsules, you can trust that you are consuming a high-quality product free from additives and GMOs.

What We Like
High-quality, vegan-friendly formula
Supports energy and motivation
Reduces fatigue effectively
Laboratory tested for purity
#TOP 9

A.Vogel St John's Wort Tablets for Mood

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A.Vogel St John's Wort Tablets for Mood Cover
A.Vogel Hyperiforce St John's Wort Tablets | Relieves Symptoms of Slightly Low Mood and Mild Anxiety | 60 Tablets

A.Vogel St John's Wort is a traditional herbal medicinal product designed to help relieve symptoms of slightly low mood and mild anxiety. If you often feel down or stressed, these tablets may provide the support you need. Made from extracts of fresh St. John's Wort, each tablet delivers a potent dose to help elevate your mood. With regular use, you can find comfort in managing feelings of stress and anxiety, making daily life more enjoyable.

What We Like
Supports slightly low mood
Helps relieve mild anxiety
Made from fresh St. John's Wort
Convenient tablet form
#TOP 10

Biopurus Certified Organic St. John's Wort Oil

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Biopurus Certified Organic St. John's Wort Oil Cover
Certified Organic St. John's Wort Infused Oil 250 ml Biopurus

Biopurus St. John's Wort Oil is a versatile infused oil that brings numerous benefits to your daily routine. Made from St. John's Wort, this food-grade oil is free from artificial preservatives and colours, ensuring a natural product for your peace of mind. Housed in an amber glass bottle, it protects the oil from light, preserving its quality. Originating from Germany, this certified organic oil is ideal for those seeking natural remedies and holistic wellness solutions.

What We Like
Organic and natural ingredients
No artificial preservatives
Food grade quality
Protective amber glass bottle
German origin
Buying Guide Image

Frequently Asked Questions (FAQs)

1. Is St John's wort a herbal supplement?

John's wort can help treat depression and other medical conditions, but experts warn there are some downsides to this herbal supplement. St. John's wort is natural. It's an herbal supplement that doesn't require a prescription and you can buy it at a health food store.

2. What is the herb St John's wort used for?

It contains many chemicals that act on messengers in the brain that regulate mood. People most commonly use St. John's wort for depression and mood disorders. There is some strong scientific evidence that it is effective for mild to moderate depression.

3. What are the benefits of taking St John's wort?

What are the potential benefits of using St. John's wort?. Reduction in symptoms of depression.Reduction in menopausal symptoms.Assistance with wound healing (when applied to the skin as a lotion)

4. How does St John's wort make you feel?

John's wort are generally mild and include stomach upset, hives or other skin rashes, fatigue, restlessness, headache, dry mouth, and feelings of dizziness or mental confusion. St. John's wort can also make the skin overly sensitive to sunlight, called photodermatitis. If you have light skin and are taking St.

Editor's Notes

During our st. john's wort supplement research, we found 27 st. john's wort supplement products and shortlisted 10 quality products. We collected and analyzed 32,904 customer reviews through our big data system to write the st. john's wort supplements list. We found that most customers choose st. john's wort supplements with an average price of £18.11.

The st. john's wort supplements are available for purchase. We have researched hundreds of brands and picked the top brands of st. john's wort supplements, including Natures Aid, HRI, Schwabe, Fitness Health, Hepatica.

Written by
Phoebe Cooper Avatar

In 2000, Phoebe Cooper graduated from the University of London as a Pharmacist. She practiced as a Pharmacist for the better part of 2 decades. Phoebe says she has worked in the majority of health sectors and has sufficient accumulated knowledge and experience. In her practice, Phoebe published a series of eBooks, one of which is titled "Good Health Good Living."